منابع مشابه
Contractile smooth muscle cells derived from hair-follicle stem cells.
AIMS We hypothesized that hair-follicle stem cells can differentiate toward smooth contractile muscle cells, providing an autologous cell source for cardiovascular tissue regeneration. METHODS AND RESULTS Smooth muscle progenitor cells (SMPCs) were obtained from ovine hair follicles using a tissue-specific promoter and fluorescence-activated cell sorting. Hair-follicle smooth muscle progenito...
متن کاملFunctional recapitulation of smooth muscle cells via induced pluripotent stem cells from human aortic smooth muscle cells.
RATIONALE Generation of induced pluripotent stem (iPS) cells has been intensively studied by a variety of reprogramming methods, but the molecular and functional properties of the cells differentiated from iPS cells have not been well characterized. OBJECTIVE To address this issue, we generated iPS cells from human aortic vascular smooth muscle cells (HASMCs) using lentiviral transduction of ...
متن کاملThe mechanism of stem cell differentiation into smooth muscle cells.
Stem cells represent one of the most promising areas in biological and medical research. All stem cells are defined as having two basic properties: unlimited self-renewal and the broad potential to differentiate in vitro, via "progenitor cells", into somatic cells of many tissue types, in which smooth muscle cell (SMC) differentiation is a complicated and not well defined process. It is known t...
متن کاملStem cells in airway smooth muscle: state of the art.
Very little is known regarding the function, origin, and turnover of airway smooth muscle (ASM). In this article, we discuss the embryological development of ASM, and provide information regarding candidate mesenchymal ASM progenitor cell populations specifically in relation to airway remodeling. This review also highlights the current limitations in studying ASM biology, and underscores the ne...
متن کاملCalcineurin initiates smooth muscle differentiation in neural crest stem cells
The process of vascular smooth muscle cell (vSMC) differentiation is critical to embryonic angiogenesis. However, despite its importance, the vSMC differentiation program remains largely undefined. Murine gene disruption studies have identified several gene products that are necessary for vSMC differentiation, but these methodologies cannot establish whether or not a factor is sufficient to ini...
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ژورنال
عنوان ژورنال: The Anatomical Record
سال: 2003
ISSN: 0003-276X,1097-0185
DOI: 10.1002/ar.a.10128